Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
Conboy IM, Wagers AJ et al. Nature, 2005.
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Loffredo FS,...,Wagers AJ, Lee RT. Cell, 2013.
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Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle.
Sinha M,...,Lee RT, Wagers AJ. Science, 2014.
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Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors.
Katsimpardi L,...,Lee RT, Wagers AJ, Rubin LL. Science, 2014.
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Olson KA et al. European Heart Journal, 2015.
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Walker RG,...,Rubin LL, Wagers AJ, Lee RT. Circulation Research, 2016.
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Structural basis for potency differences between GDF8 and GDF11.
Walker RG,...,Wagers AJ, Lee RT et al. BMC Biology, 2017.
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Onodera K et al. Thorax, 2017.
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Lifelong exercise, but not short-term high-intensity interval training, increases GDF11.
Elliott BT et al. Physiological Reports, 2017.
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Ozek C,…, Rubin LL. Scientific Reports, 2018.
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Molecular characterization of latent GDF8 reveals mechanisms of activation.
Walker RG,...,Lee RT et al. PNAS, 2018.
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GDF11 Rejuvenates Cerebrovascular Structure and Function in an Animal Model of Alzheimer’s Disease.
Zhang et al. Journal of Alzheimer’s Disease, 2018.
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Ma et al., Brain Research, 2018.
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Neuroprotective potential of GDF11 in experimental intracerebral hemorrhage in elderly rats.
Xiao et. al. Journal of Clinical Neuroscience, 2019.
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GDF11 Promotes Neurovascular Recovery After Stroke in Mice
Xiao et al. J. Clinical Neuroscience, 2019.
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GDF11 Improves Angiogenic Function of EPCs in Diabetic Limb Ischemia.
Zhang et al. Diabetes, 2018.
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Growth differentiation factor 11 (GDF11) has pronounced effects on skin biology.
Idkowiak-Baldys J,…, Rubin LL. PLoS ONE, 2019.
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Katsimpardi et al. Aging Cell, 2019.
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