Key Publications


Nature feature article providing high level overview: Blood to blood - By splicing animals together, scientists have shown that young blood rejuvenates old Tissues.

Conboy IM, Wagers AJ et al. Nature, 2005. Rejuvenation of aged progenitor cells by exposure to a young systemic environment.

Loffredo FS, Wagers AJ, Lee RT et al. Cell, 2013. Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy.

Sinha M, Lee RT, Wagers AJ et al. Science, 2014. Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle.

Katsimpardi L, Lee RT, Wagers AJ, Rubin LL et al. Science, 2014. Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors.

Olson KA, Ganz P et al. European Heart Journal, 2015. Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans.

Walker RG, Rubin LL, Wagers AJ, Lee RT, et al. Circulation Research, 2016. Biochemistry and Biology of GDF11 and Myostatin Similarities, Differences, and Questions for Future Investigation.

Walker RG, Wagers AJ, Lee RT, et al. BMC Biology, 2017. Structural basis for potency differences between GDF8 and GDF11.

Walker RG, Lee RT, et al. PNAS, 2017. Molecular characterization of latent GDF8 reveals mechanisms of activation.

Elliott BT, et al. Physiological Reports, 2017. Lifelong exercise, but not short-term high-intensity interval training, increases GDF11.

Onodera K et al. Thorax, 2017. Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease.

Li et al., Diabetes, 2017. GDF11 Attenuates Development of Type 2 Diabetes via Improvement of Islet β-Cell Function and Survival.

Bajikar et al. Dev Cell, 2017. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.

Zhang et al. Journal of Alzheimer’s Disease, 2018. GDF11 Rejuvenates Cerebrovascular Structure and Function in an Animal Model of Alzheimer’s Disease. 

Ma et al., Brain Res, 2018. GDF11 improves neurobehavioral recovery and stimulates angiogenesis in rats subjected to cerebral ischemia/reperfusion.